Why Are People Obsessed With Fisetin? - Part 2

Written by Anil Bajnath, MD
Posted November 11, 2021

Dear Longevity Insider,

Folks just can't get their hands on enough fisetin. Fisetin is a naturally occurring antioxidant found in many fruits and vegetables. Fisetin is known as a neuroprotective agent, meaning it has been shown to have potential benefits in helping the body fight against both acute and chronic neurological diseases.

Fisetin is one of the most common and bioactive flavonoids which possesses potential neuroprotective effects. Studies show that fisetin can also enhance learning and memory, decrease neuronal cell death, and suppress oxidative stress. 

Oxidative stress refers to the level of damage done to cells in the body by free radicals. Fisetin has been shown to have some effect against oxidative stress, but it is not yet known whether fisetin itself can actually reduce oxidative stress or if fisetin can enhance antioxidants that are already present in the body. The possibilities are endless... Fisetin may work as a scavenger (it can bind to free radicals). It also could be regenerating the antioxidants that it is acting with, or fisetin itself may act as an antioxidant. There is still much to learn about fisetin.

FISETIN AND LONGEVITY

As we age, we accumulate damaged cells. Damaged cells can cause tissues to function improperly or not work at all. Fisetin has been shown to reduce senescent cell burden in mice by activating the body's enzymes that clear out senescent cells. Senescent cells are cells that have stopped dividing to replicate themselves. Senescent cells can accumulate in all tissues with age and secrete pro-inflammatory cytokines and chemokines. Fisetin has been shown to increase the lifespan of mice. In a recent study, administration of fisetin to wild-type mice late in life restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan. 

  • Fisetin and mTOR. The mTOR is responsible for controlling cell growth, division, and metabolism. Recent research shows how fisetin inhibits the mTOR pathway. When you inhibit the mTOR pathway you are essentially slowing down the aging process.

  • Fisetin and Inflammaging. Inflammaging refers to the chronic low-grade inflammation that is caused by cellular damage, oxidative stress, and mitochondrial dysfunction. Fisetin is believed to be able to reduce inflammation because fisetin has shown an ability to reduce cellular (nuclear) damage in animal studies. This is accomplished by fisetin's ability to inhibit pro-inflammatory enzymes and substances, like lipoxygenases and NF-kB.

MORE RESEARCH

As research continues on this compound, more information about how fisetin could be used for medicinal purposes will be revealed. Fisetin holds great potential for multiple applications in medicine, and research studies have shown fisetin's positive anti-inflammatory and anti-cancer effects on different cell types. Over the last two decades, much attention has been drawn to plant-derived bioactive compounds as novel therapeutic agents for treatment of neurodegenerative diseases such as Alzheimer's disease (AD) and Parkinson's disease (PD). The current research suggests that the benefits of fisetin may be worth considering for those looking for natural options to improve their health.

Here's my latest research on fisetin (and four other super nutrients). You'll be amazed by what you learn in this presentation.

To your longevity,

Anil Bajnath MD
CEO/Founder, Institute for Human Optimization
Chief Medical Officer, Longevity Insider HQ