Why Are People Obsessed With Fisetin? - Part 1

Written by Anil Bajnath, MD
Posted November 9, 2021

Dear Longevity Insider,

Fisetin is a naturally occurring flavonoid compound. Flavonoids are water-soluble compounds found in plants and have antioxidant properties. Water-soluble means that fisetin can dissolve in water. Fisetin is not found to be fat-soluble, which means it cannot dissolve into fats or lipids that are normally soluble in oils.

Fisetin was isolated from the fruiting bodies of a fungus called Fomes fomentarius. The fruiting body of this fungus is responsible for producing all of the spores that are used to reproduce. Fisetin can also be found in many plants including ginkgo biloba, strawberries, and persimmons. Fisetin's chemical structure was first identified in 1891 by Josef Herzig, who was able to synthesize fisetin from luteolin, another naturally occurring flavonol compound derived from Foeniculum vulgare. Luteolin, unlike fisetin, is found in high concentrations in fennel. Fisetin can be found throughout the plant kingdom, where it acts as a photosynthesis inhibitor and UV protectant. Fisetin has even been isolated from insects, including ants, aphids, and wasps.

Fisetin is also said to be one of the many flavonoids that are found abundantly in the plant subfamily Cornoideae, which includes Foeniculum vulgare, Foeniculum dulce, and Coriandrum sativum. Fisetin was first isolated from Foeniculum vulgare, fennel. Fisetin was first isolated from the bark of the Pacific wax myrtle tree and has since been found in many fruits and vegetables. Fruits and vegetables that are high in fisetin include:

  • Strawberries (fisetin's highest food source).
  • Red grapes.
  • Apples.
  • Asian pears.
  • Fennel seeds (Foeniculum vulgare)

Fisetin is a member of the flavonoids, which are plant pigments produced by many plants to help protect themselves from outside stressors, such as ultraviolet light, insects, and herbivores. 

Why Are People Taking Fisetin?

Natural supplements are becoming increasingly popular in the health and wellness community. There are a number of different types of natural supplements such as probiotics, prebiotics, digestive enzymes, amino acids, and herbal extracts that all serve their own specific purposes. There are many reasons why people take natural supplements. Some people want to support their body's natural processes. Others want natural help with a specific health concern. And some just want to maintain good health.

Dietary supplements have been one way that consumers have sought to fulfill unmet dietary needs. Fisetin is one of many supplements like this that people are turning to attempt to make themselves feel better. Many of my patients opt to take supplements to make sure they get enough essential nutrients and to maintain or improve their health. 

I've always been fascinated by fisetin and the effects it can have on the body. Here's my latest research on it, as well as four other specialized nutrients.

To your longevity,

Anil Bajnath MD
CEO/Founder, Institute for Human Optimization
Chief Medical Officer, Longevity Insider HQ