The Fight Against Obesity: Gene-Edited Fat Cells?

Written by Alex Reid
Posted September 14, 2020

Hi y’all!

Alex Reid here with your Monday roundup.

How did you spend one of the last weekends of summer?

Most Americans lit up the grill, invited a friend or two over, and threw back a few brews.

If you find that you’ve been consuming more than just a couple beers here and there… you may have noticed a change in physique.

Perhaps, you’ve developed the God-awful “beer belly” or you’ve suddenly started noticing your “love handles.”

If this sounds familiar… don’t worry. 

Scientists recently released more data on “fat” transplants…

And what that can mean for the future.

When you hear the word “fat,” you probably think of unhealthy foods or the body type I described a bit ago…

The truth is, there are two types of fat: white fat and brown fat. White fat is what you see with those love handles. But brown fat is the kind that gets turned into energy!

(This is the type of fat most people like.) 

How great would it be if all of our fat was turned into energy instead of being stored in our bodies?



Thanks to a recent gene-editing technique, scientists have found a way to convert a person’s own white fat into brown fat.

This fat could then be transplanted in an effort to treat obesity and diabetes...

HUMBLE Cells

Columbia University ran a study in 2018 proving the effectiveness of turning white fat into brown fat.

Recently, scientists at the Joslin Diabetes Center ran a similar study but used the CRISPR, a gene-editing tool to manipulate the cells early on in the developmental stage.

Instead of waiting to harvest white cells in their mature state, the scientists harvested them in the progenitor phase. 

Meanwhile, scientists used the CRISPR to increase the expression of an important gene known as UCP1. It’s responsible for converting the “premature” white cells into a brown-like cells. The team has labeled these human brown-like fat cells as “HUMBLE” cells.

And the results from their studies were incredible.

And the senior author of the study, Yu-Hua Tseng, adds:

"Employing cell-based or gene therapies to treat obesity or type 2 diabetes used to be science fiction. Now scientific advances, such as CRISPR gene-editing technologies, will help us to improve the metabolism, the body weight, the quality of life and the overall health of people with obesity and diabetes."

Tseng and his team have high hopes for this gene-editing therapy and what it can imply for those with obesity and diabetes (which is commonly caused by obesity).



It all reminds me of my weight loss journey.

I didn’t do anything ridiculous with my eating habits. I didn’t workout 24/7 either.

But what I did do is tried this MCT oil.

It can help people lose upwards of 460 calories a day.

For me, I dropped 40 pounds and three pant sizes.

To your health,

Alex Reid
President, Longevity Insider HQ



P.S. Stay tuned. Tomorrow, Anil Bajnath MD continues his series on neurotransmitters and how they affect your brain.