LATEST STUDY: Experimental Drug Reverses Cognitive Decline

Written by Alex Reid
Posted December 7, 2020

Hi y’all!

Alex Reid here with your Monday roundup.

I want to see 100.

But not the “100” you imagine with someone who stays in bed all day; eats prunes, pudding, and jello; and counts his finals days...

That’s not living. I want my 100 to look like…

  • Taking the boat out on the harbor…
  • Traveling to Europe with my spouse…
  • Going to my great-grandchildren’s sporting events…
  • Having meaningful moments and conversations (that I actually remember).

When it’s time to leave this Earth, I’m going out with a bang! Not as a vegetable.

It’s for these very reasons that I prioritize my health: my body, mind, and spirit.

Of my daily rituals, I take moringa, vitamin K2, and vitamin D3 every single morning. I need as much energy, focus, strength, and brainpower that I can muster. And I'm always on the prowl for more useful information.

So here’s what crossed my desk recently…

Researchers revealed an experimental drug that reversed cognitive decline in mice. When I heard this, it made me think of a family member of mine who recently passed.

He had Alzheimer's disease… and I often wonder what could have been if he took better care of himself… if he did more to stimulate his mind… if he exercised more.

During his final days, he was bedridden essentially… he couldn't get out of bed... yet alone walk.

So when I hear of experiments like these, they grab my attention for multiple reasons.

The obvious reason is you.

I’m always searching through the most interesting research I can find to help you stay one step ahead of the herd.

Researchers have shown before that this experimental drug, named ISRIB, could be used to:

  • Restore memory function months after traumatic brain injury (TBI).
  • Reverse cognitive impairments in Down Syndrome.
  • Prevent noise-related hearing loss.
  • Fight certain types of prostate cancer.
  • Enhance cognition in healthy animals.

And now there’s one more thing researchers are adding to the list of ISRIB’s brag sheet… thanks to a recent study on mice.

Susanna Rosi, PhD, Lewis and Ruth Cozen Chair II and professor in the departments of Neurological Surgery and of Physical Therapy and Rehabilitation Science, says:

“ISRIB’s extremely rapid effects show for the first time that a significant component of age-related cognitive losses may be caused by a kind of reversible physiological ‘blockage’ rather than more permanent degradation.”

Peter Walter, PhD, a professor in the UCSF Department of Biochemistry and Biophysics and a Howard Hughes Medical Institute investigator, explains how it’s possible to regain cognitive ability once thought lost:

“The data suggest that the aged brain has not permanently lost essential cognitive capacities, as was commonly assumed, but rather that these cognitive resources are still there but have been somehow blocked, trapped by a vicious cycle of cellular stress. 

“Our work with ISRIB demonstrates a way to break that cycle and restore cognitive abilities that had become walled off over time.”

More on the study here.

But before I let you go…

When it comes to anti-aging, the experiments, theories, and possibilities are endless.

So our Chief Medical Advisor, Dr. Anil Bajnath, wants to let you in on a little secret.

(Hint: It doesn’t involve anything “experimental.”)

To your health,

Alex Reid
President, Longevity Insider HQ



P.S. Tomorrow you'll hear from Dr. Anil with Part 2 of his Biometrics series.