A New Way to Prevent Sudden Cardiac Death?

Written by Alex Reid
Posted February 22, 2021

Hi y’all!

Alex Reid here with your Monday roundup.

On my path to longevity, I’m always researching, reading, and studying.

From biotechnology to brain food… Here at Longevity Insider HQ, we cover everything related to living a long, healthy life.

Today, we put the spotlight on heart health.

Every single year, almost 500,000 American people die from sudden cardiac death (SCD).

SCD happens when the heart’s electrical system malfunctions. And one of the primary causes for SCD (particularly in young athletes) is ACM.

ACM stands for arrhythmogenic cardiomyopathy. It’s a genetic disease in which scar tissue and fat over time replace healthy heart tissue.

Along with the ACM comes arrhythmias (strange heart rhythm problems). And unlike healthy-hearted people, exercise can do more harm than help to those with ACM. Most people exercise to keep a healthy heart. Some folks with ACM may avoid exercise altogether for the very same reason.

Stephen Chelko, an assistant professor of biomedical sciences at the Florida State University College of Medicine, adds:

There is some awful irony in that exercise, a known health benefit for the heart, leads to cell death in ACM subjects.

Now, we know that endurance exercise, in particular, leads to large-scale myocyte cell death due to mitochondrial dysfunction in those who suffer from this inherited heart disease.

Ultimately, mitochondria become overwhelmed and expel “death signals” that are sent to the nucleus, initiating large-scale DNA fragmentation and cell death.

This novel study unravels a pathogenic role for exercise-induced, mitochondrial-mediated cell death in ACM hearts.

Due to his extensive research, Chelko discovered a way to prevent said cell death. And it can be done by inhibiting these two different mitochondrial proteins.

To your health,

Alex Reid
President, Longevity Insider HQ

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